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Diosmin Citrus Aurantium

What Is Diosmin?

Diosmin is a naturally occurring flavonoid glycoside that can be isolated from various plant sources or derived from the flavonoid hesperidin. Diosmin was first isolated in 1925 from Scrophularia nodosa, and first introduced as a therapeutic agent in 1969.  Diosmin is a biogenic amine derived by extracting hesperidin from Citrus Aurantium L., followed by conversion of hesperidin to diosmin. Diosmin is considered to be a vascular-protecting agent used to treat chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins. As a flavonoid, diosmin also exhibits anti-inflammatory, free-radical scavenging, and antimutagenic properties. Diosmin has been used for more than 30 years as a phlebotonic and vascular protecting agent, and has recently begun to be investigated for other therapeutic purposes, including cancer, premenstrual syndrome, colitis, and diabetes.

Main Functions And Benefits Of Diosmin:

1. Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis.

2. Diosmin increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.

3. Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries.

4. Diosmin powder with hesperidine decreases the diameter of lymphatic capillaries and the intralymphatic pressure.

5. At the microcirculation level, diosmin reduces capillary hyperpermeability and increases capillary resistance by protecting the microcirculation from damaging processes.

6. Diosmin reduces the expression of endothelial adhesion molecules,and inhibits the adhesion, migration, and activation of leukocytes at the capillary level. Diosmin powder leads to a reduction in the release of inflammatory mediators, principally oxygen free radicals and prostaglandins.

Applications Of Diosmin:

1. Diosmin can be used as raw material for medicines in pharmaceutical field.

2. Diosmin can be used as raw material in health care product and supplement field. 

Specifiction:

Analysis   Items	Specifications	Test   Methods
Identification	Positive	TLC
Appearance & Color	Light yellow crystalline powder	Visual
Odor & Taste	Characteristic	Organoleptic
Mesh Size	NLT 99% through 80 mesh	80 Mesh Screen
Solubility	Soluble in hydro-alcoholic solution	Visual
Assay	NLT 95% Diosmin	HPLC
Loss on drying	NMT 5%	5g / 105? / 2hrs
Ash	NMT 5%	2g / 525? / 3hrs
Excipient	None	/
Heavy Metals	NMT 10mg/kg	Atomic Absorption
Arsenic (As)	NMT 2mg/kg	Atomic Absorption
Lead (Pb)	NMT 1mg/kg	Atomic Absorption
Cadmium (Cd)	NMT 0.3mg/kg	Atomic Absorption
Mercury (Hg)	NMT 0.1mg/kg	Atomic Absorption
Total Plate Count	NMT 1,000cfu/g	GB 4789.2-2010
Total Yeast & Mold	NMT 100cfu/g	GB 4789.15-2010
E. Coli	Negative	GB 4789.3-2010
Salmonella	Negative	GB 4789.4-2010
Staphylococcus	Negative	GB 4789.10-2010