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HG009072 -----Gamabufotalin

analytical standard

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Synonym:	Gamabufogenin; Gamabufagin; Gammabufotalin
Cas Number:	465-11-2
Molecular Formula:	C24H34O5
Molecular Weight:	402.52
Chemical Name:	3-beta,11-alpha,14-Trihydroxy-5-beta-bufa-20,22-dienolide
Appearance:	White powder
Grade:	analytical standard
Assay:	=98%(HPLC)
Chemical Family:	Bufadienolides compounds
Original:	Bufo bufo gargarizans Cantor
Storage temp:	2~8°C
Pack Size:	20mg; 100mg; 1gram ;10gram
Application:	For laboratory research use only

 

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Item and Name	Pack Size	Price(USD)	Payment
HG009072--Gamabufotalin	20mg	215.00	PayPal
HG009072--Gamabufotalin	100mg	635.00	PayPal
HG009072--Gamabufotalin	500mg	1220.00	PayPal
HG009072--Gamabufotalin	1g	1885.00	PayPal

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Articles:

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1.Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer.

Zhang L, Yu Z, Wang Y, Wang X, Zhang L, Wang C, Yue Q, Wang X, Deng S, Huo X, Tian X, Huang S, Zhang B, Ma X.

PMID: 27384878

Abstract

Gamabufotalin (CS-6) is a major bufadienolide of Chansu, which shows desirable metabolic stability and less adverse effect in cancer therapy. CS-6 treatment inhibited the proliferation 

of NSCLC in a nanomolar range. And CS-6 could induce G2/M cell cycle arrest and apoptosis in A549 cells. However, its ---Read More

2.Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway.

Tang N, Shi L, Yu Z, Dong P, Wang C, Huo X, Zhang B, Huang S, Deng S, Liu K, Ma T, Wang X, Wu L, Ma XC.

PMID: 26657289

Abstract

Gamabufotalin (CS-6), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer cell growth and inflammatory response. However,

 its effects on angiogenesis have not been known yet. Here, we sought to determine the biological ---Read More