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Lappaconitine
IUPAC name :
(1a,14a,16b)-20-Ethyl-1,14,16-trimethoxyaconitane-4,8,9-triol4-(2-ace tylamino)benzoate)
CAS No.: 32854-75-4
Molecular formula:C₃₂H₄₄N₂O₈
Molecular weight: 584.64
M.P.:224~225°C (lit.)
B.P.:218 °C  2 mm Hg(lit.)
Appearance:  white columnar crystals
Content:98% HPLC
Description:
Lappaconitine is an alkaloid isolated from the root of Aconltitum sinomantanum Nakai. It has a strong analgesic activity that does not involve the opioid receptor. It was shown to have class-I antiarrhythmic action and irreversibly blocks cloned human heart (hH1) channels by binding to the site 2 receptor. It is a non-narcotic central nervous system analgesic. Lappaconitine also has antiarrhythmic and anti-inflammatory effect. Lappaconitine works as an inhibitor of tetrodotoxin-sensitive, voltage-dependent sodium channels. On the other hand, lappaconitine is reported as an organocatalyst for asymmetric a-hydroxylation of ß-keto esters.