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plasmapheresis method is to flow a patient's blood into the plasma exchange device, and discard the plasma containing a large number of isolated autoantibodies, immune complexes, plasma inflammatory pathogenic factors , and add some fresh plasma or substitutes, such as 4% human serum albumin, Ringer's solution, etc., to get rid of soluble immune complexes and some antibodies. Before treatment, some patients have high levels of circulating immune complexes, but after treatment, levels of circulating immune complexes is decreased significantly, all the symptoms get rapidly improvement. In the clinical treatment of some Systemic Lupus Erythematosus, especially when patients with severe lupus, the Plasmapheresis Method has a very significant effect.