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Chemical Name:Teriparatide
CAS# 52232-67-4
Sequence: Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
Molecular Formula: C181H291N55O51S2
Molecular Weight: 4117.72
Indication:
it is effective in women with postmenopausal osteoporosis, men with idiopathic or hypogonadal osteoporosis and patients with glucocorticoid-induced osteoporosis. Teriparatide improves bone mineral density (BMD) and alters the levels of bone formation and resorption markers; histomorphometric studies showed teriparatide-induced effects on bone structure, strength and quality.
TEST ITEMS | SPECIFICATIONS | RESULTS |
Appearance | White powder | Conforms |
Solubility | Soluble in water or 1% acetic acid | Conforms |
Specific Optical Rotation(c=0.5,1% HAc) | - -65.0~-75.0° | -70.2° |
Identity | Monoisotopic Mass: 4117.7±2.0 | 4116.0 |
Amino Acid Composition | ±20% | Conforms |
Related Substances
| Total Impurities(%)= 5.0% Largest Single Impurity(%)= 2.0% | 0.8% |
Peptide Purity (By HPLC) | = 95.0% by area integration | 99.3% |
Acetate Content | = 15% | 9.0% |
Water Content(Karl Fischer) | = 8.0% | 2.5% |
Peptide Content(N determination) | = 80.0% | 88.3% |
Assay(By Anhydrous, Acetic Acid-free ) | 95.0~105.0% |
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