This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse TGF-ß1. The Mouse TGF-ß1 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Transforming growth factor beta 1 (TGF-ß1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines that performs many cellular functions, including the control of cell growth,cell proliferation, cell differentiation and apoptosis. TGF-ßs are a multifunctional set peptides that controlsproliferation, differentiation, and other functions in many cell types. TGF-ßs act synergistically with TGFA in inducingtransformation. It also acts as a negative autocrine growth factor. Dysregulation of TGF-ß activation and signaling may result in apoptosis. Many cells synthesize TGF-ß and almost all of them have specific receptors for this peptide. TGF-ß1, TGF-ß2 , and TGF-ß3 all function through the same receptor signaling systems. TGF-ß1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (orleukocytes) secrete TGF-ß1.