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Basic information Betamethasone CAS NO 378-44-9

Product Name: Betamethasone 

Molecular Formula : C22H29FO5

Molecular Weight: 392.46

CAS No.: 378-44-9

Appearance: White crystalline powder

Specifications:

EP8/BP2013

Usages :

Betamethasone is a corticosteroid product. it is used for a number of diseases including:

1)Rheumatic disorders such as systemic lupus erythematosus. 

2)Skin diseases such as dermatitis and psoriasis, 

3)Allergic conditions such as asthma and angioedema

4)Leukemia

Items	Specifications	Results
Appearance	White or almost white, crystalline powder	White crystalline powder
Identification(by IR )	Conforms to the CRS spectrum	Conforms
Specific optical rotation	+118°~+126°(dried substance )	+123.2°
Related substances(by HPLC)	Impurity C (RRT about 1.64)=0.5% Impurity D (RRT about 2.0)=0.10% Impurity E (RRT about 1.48)=0.5% Impurity J (RRT about 1.68)=0.5% Unknown Impurity (RRT about 0.49)=0.15% Unknown Impurity (RRT about 0.92)=0.15% Unspecified impurities =0.10% Total impurities =1.3%	0.12% Undetected 0.19% 0.32% 0.12% 0.11% 0.08% 0.99%
Loss on drying	=0.5%	0.2%
Assay (by UV)	Contains 97.0% to 103.0% of C22H29FO5 Calculated on dried basis	99.4%
Conclusion	The results can conforms with the EP8/BP2013

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